League of Legends (LoL) Question: can you dodge ezreals homing bolt or will it follow your target lets say if

Assuming you mean if he uses Essence Flux and then Arcane Shift in which case no you can't dodge it unless he uses his E from very far away to the point where the E damage isn't in range to hit you since the ability prioritizes targets that get hit by Essence Flux.

Since otherwise he'd just need to use a Q or R to proc it, which would be trying to hit a skillshot.